Resveratrol Clinical Study

New Resveratrol Tetramers from the Stem Bark of Upuna borneensis.

Ito T, Ali Z, Furusawa M, Iliya I, Tanaka T, Nakaya K, Murata J, Darnaedi D, Oyama M, Iinuma M.

Gifu Prefectural Institute of Health and Environmental Sciences, 1-1 Naka-fudogaoka, Kakamigahara 504-0838, Japan (phone: +81-583-80-2120; fax: +81-583-71-5016).

Five new resveratrol (=5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol) tetramers, upunaphenols H-J (1-3) and trans-(4) and cis-upunaphenol K (5), were isolated from the stem of Upuna borneensis (Dipterocarpaceae). Their structures were elucidated on the basis of 1D- and 2D-NMR as well as FAB-MS data. Compounds 1-3 bear a rare biphenyl bond in their frameworks. Compounds 1 and 2 have an unprecedented nonacyclic fused ring system, and compounds 2 and 3 have symmetrical structures.

PMID: 17191964 [PubMed - in process]

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