Resveratrol Clinical Study

Two Novel Trimeric Resveratrol Derivatives from Cotylelobium lanceolatum.

Ito T, Ali Z, Furusawa M, Iliya I, Tanaka T, Nakaya K, Murata J, Darnaedi D, Oyama M, Iinuma M.

Gifu Prefectural Institute of Health and Environmental Sciences, 1-1 Naka-fudogaoka, Kakamigahara 504-0838, Japan (phone: +81-583-80-2100; fax: +81-583-71-5016).

Two new resveratrol (=5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol) trimers, cotylelophenols A (1) and B (2), were isolated from the stem of Cotylelobium lanceolatum (Dipterocarpaceae), together with ten known resveratrol oligomers (3-12). The structures of the isolates were established on the basis of spectroscopic analyses, including a detailed NMR spectroscopic investigation of 1 under different conditions. Compound 1 is the first resveratrol trimer with a rearranged 4-hydroxyphenyl group. Four possible biogenetic pathways towards resveratrol oligomers are proposed (Scheme).

PMID: 17193203 [PubMed - in process]

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