Resveratrol Clinical Study

Synthesis and Cytotoxic Evaluation of a Series of Resveratrol Derivatives.

Ruan BF, Huang XF, Ding H, Xu C, Ge HM, Zhu HL, Tan RX.

Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone: +86-25-8359 2085; fax: +86-25-8330 2728).

A total of 17 resveratrol (=(E)-5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol) derivatives were synthesized from resveratrol (RES) through a facile approach. Among them, 13 compounds, 2 and 6-17, were reported for the first time, while 1 and 3-5 had already been reported several years ago. The cytotoxic activities of these compounds were evaluated against human nasopharyngeal epidermoid tumor cell line KB, and compounds 1 and 8-11 showed strong anticancer activities in vitro, comparable with that of 5-fluorouracil, an anticancer drug. On the basis of the experimental data obtained, structure-activity relationships are discussed.

PMID: 17193329 [PubMed - as supplied by publisher]

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