SAM-e (S-Adenosyl-l-Methionine)

SAM-e S Adenosyl l Methionine is a manufactured form of a chemical which is produced naturally in the body.

S-adenosyl methionine (SAM) is a cofactor involved in methyl group transfers. SAM was first discovered in 1952. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase EC 2.5.1.6. Transmethylation, transsulfuration and aminopropylation are the metabolic pathways that use SAM. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver.

The methyl group (CH3) attached to the methionine sulfur atom in SAM is chemically reactive. This allows donation of this group to an acceptor substrate in transmethylation reactions. More than 40 metabolic reactions involve the transfer of a methyl group from SAM to various substrates such as nucleic acids, proteins and lipids.

SAMe Clinical Studies

• S-adenosylmethionine (SAM-e) for the treatment of depression in people living with HIV/AIDS.
• S-adenosylmethionine and radical-based catalysis.
• The effect of ethanol, ethanol metabolizing enzyme inhibitors, and Vitamin E on regulating glutathione, glutathione S-transferase, and S-adenosylmethionine in mouse primary hepatocyte.
• S-adenosylmethionine: jack of all trades and master of everything?
• Effect of S-adenosylmethionine on age-induced hepatocyte damage in old Wistar rats.

SAMe News Articles

• Self-Medicating With SAM-e
• SAM-e: The antidepressant celebrity
• SAM-e

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