L-Glutathione News

Thursday, 26 August 2004

The life sustaining activities of each human cell paradoxically and insidiously expose that cell to mortal danger. Free radicals, molecules with an electrical charge, are highly reactive with other molecules throughout the cell. This reactivity makes possible numerous essential cellular functions such as utilization of the chemical energy of nutrients into the conversion of ADP to ATP. However, an excess of free radicals exposes healthy tissues, especially DNA and cellular membranes, to potentially highly damaging, mutating and diseasecausing oxidative stress.

Superoxide Dismutase (SOD) dismutates, or quenches, one of the most highly reactive free radicals, the Superoxide radical, catalyzing its combination into a much less reactive molecule. The SOD, which is produced by every cell, catalyzes the production of other important antioxidant enzymes, catalase and L-glutathione peroxidase, which also have essential responsibilities for the modulation of the level of free radicals at the cellular level. SOD levels have an important positive influence on the overall maintenance of a healthy immune system and the control of inflammatory cytokines.

GliSODin reduces oxidative stress in humans.

SOD was isolated about 30 years ago by Professor Joseph McCord at the University of Colorado. Bovine liver and other animal tissues were identified as rich sources of this enzyme.

* GliSODin(TM) is the first oral administered form of Superoxide dismutase with clinical evidence of it increasing the levels of SOD, catalase, and L-glutathione peroxidase. It is a combination of a melonderived SOD and gliadin, a wheat protein, and is covered by several U.S. patents: 6,045,809 and 6,426,06881, with several additional patents forthcoming. This product must be carefully distinguished from existing orally ingested SOD products in the market, which are denatured by the time they reach the cells of the intestine for absorption.

The three enzymes whose levels are enhanced by GliSODin are absolutely fundamental antioxidant enzymes responsible for the proper regulation of free radicals in each cell of the body. Levels of the body's SOD decline with age and in the course of numerous disease states, notably in situations where the immune system is weakened. SOD provided by injection has a long history of demonstrated efficacy in reducing oxidative stress (Carl Germano's book, of which a second edition with the recent clinical results should be forthcoming by the end of this year)1. A nutritional supplement featuring GliSODin is currently being supplied by prescription to individuals with reduced SOD levels, and it is reimbursed by Medicaid in seven or more states.

* An in vitro study with human Caco-2 cells demonstrates a dramatic uptake by these cells of GliSODin (made to fluoresce for visual effect), whereas the pure SOD, pure gliadin or the control do not show such an effect.

* Depressed blood SOD levels in an African test group were raised to normal levels by GliSODin dosing, strongly indicating GliSODin's oral effectiveness.

* Two studies in mice showing that GliSODin significantly improved levels of these enzymes in the body and reduction of oxidative stress have been accepted for publication this year in peer reviewed journals. Specific results include a significant protection against hepatocystic apoptosis in rats as well as increases in SOD, catalase and L-glutathione peroxidase.

* Several as yet unpublished human studies have been conducted showing that GliSODin reduces oxidative stress in humans:

I protection of DNA in accelerated oxidative stress trial using hyperbaric chamber in UIm Germany hospital. The "comet assays" revealed that dosing with GliSODin for several weeks before entering the chamber dramatically reduced cellular DNA damage, lsoprostain levels in the urine, another very important marker of oxidative stress, were also reduced by prior GliSODin dosing.

I reduction in lactate levels in blood serum after strenuous exercise conducted on 44 subjects in Korea, supporting similar results obtained in earlier Japanese studies. Lactate levels are a measure of muscle breakdown and fatigue.

* GliSODin ingestion has now been shown to modulate within normal levels the body's own "endogenous" SOD, the body's master defense enzyme.

For more information about GliSODin(TM), please e-mail P.L. Thomas, & Co., Inc. atglisodin@plthomas.com.

Reference: 1. Sod/Gliadin: The Ultimate Defense Against Disease and Aging, by Carl Germano, R.D. CNS, LDN. (Twin Streams, a Kensington Publication, 2001).

These statements have not been evaluated by the FDA.

The product is not intended to diagnose, treat, cure or prevent any disease.

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