Fucoxanthin Clinical Study

Nishino H, Tsushima M, Matsuno T, Tanaka Y, Okuzumi J, Murakoshi M, Satomi Y, Takayasu J, Tokuda H, Nishino A, et al.

Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.

We have reported that fucoxanthin, a natural carotenoid, inhibited the growth of human neuroblastoma GOTO cells. In the present study, we show that a metabolite of fucoxanthin, halocynthiaxanthin, which is isolated from sea squirt Halocynthia roretzi, has a more potent inhibitory effect. Halocynthiaxanthin (5 micrograms/ml) caused complete suppression of GOTO cell proliferation, whereas fucoxanthin reduced the growth rate by only 88.8% compared with the control, at day 2 after the drug treatment. Furthermore, halocynthiaxanthin also inhibited the growth of other human malignant tumor cells. Thus halocynthiaxanthin seems to be a promising anti-neoplastic agent.

PMID: 1450444 [PubMed - indexed for MEDLINE]

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