Aloe Vera Production Clinical Study
Two functionally and chemically distinct immunomodulatory compounds in the gel of Aloe vera.
Hart LA, van Enckevort PH, van Dijk H, Zaat R, de Silva KT, Labadie RP.
Department of Chemical Pharmacy, Faculty of Pharmacy, State University of Utrecht, The Netherlands.
An aqueous extract of Aloe vera gel was analyzed guided by modulatory activity with regard to the in vitro activation of human complement and of human polymorphnuclear leucocytes (PMN). Upon ultrafiltration a high (h-Mr) and a low (l-Mr) molecular mass fraction were obtained. Pre-incubation of human pooled serum with the h-Mr fraction resulted in a depletion of classical and alternative pathway complement activity. In contrast, only the l-Mr fraction could inhibit the production of free oxygen radicals by activated PMNs. The latter activity cannot be attributed to non-specific effects like toxicity, interference with stimulant binding or scavenger activity.
PMID: 2843719 [PubMed - indexed for MEDLINE]
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